Categories Drug Discovery
Intact MS (Intact protein mass spectrometry) provides a holistic profile of a biotherapeutic, helping to confirm predictive masses, analyze product...
Developed in the 1990s, Surface plasmon resonance technology (SPR) offers an innovative methodology for detecting interactions between ligands and analytes...
Affinity selection-mass spectrometry (AS-MS) integrates protein affinity purification methods with small molecule mass spectrometry (MS) techniques, offering...
Protein-based macromolecular drugs, typically organic compounds with molecular weights exceeding 1000, depend on cellular biosynthesis and are also known as...
Bioactive peptides are short protein fragments of 2-50 amino acids in length that are linked by covalent bonds (called amide bonds or peptide bonds)....
Sulfhydryl and disulfide bonds often participate in enzymatic catalysis, cofactor binding, and maintenance of protein active conformations in the form of...
Hydrogen deuterium exchange mass spectrometry (HDX MS) represents a sophisticated technique in mass spectrometry for investigating the spatial conformation...
In recent years, with the progress in the field of drug discovery, circular dichroism (CD) has become one of the core technologies for protein and peptide...
Molecular weight is one of the main characteristic parameters of proteins, which is an important prerequisite for determining a protein and carrying out...
During antibody production, different levels of heterogeneity usually occur, potentially affecting antibodies' biological function. One of the primary...
HPLC peptide mapping analysis is based on the molecular weight and amino acid composition characteristics of the protein, a proteolytic enzyme of strong...
Molecular weight, as a key characteristic parameter of proteins, is crucial for identifying specific proteins and conducting subsequent protein research...
mRNA medication is a novel therapeutic method that utilizes messenger RNA (mRNA). mRNA is a sequence of ribotide that encodes for proteins and can express...
Antibody therapies leverage human immune system antibodies to treat diseases by targeting specific proteins on pathogens or abnormal cells with exceptional...
Vaccines are biological products used to prevent infectious diseases. They stimulate the human immune system by mimicking infections caused by pathogens such...
In modern drug discovery and development processes, drug targets and mechanisms of action remain the two biggest challenges. The correct drug target not only...
Research on Media Development and Optimization Culture media are essential mixtures designed to support the growth and metabolism of microorganisms, cells,...
Generic peptide pharmaceuticals are products that replicate existing peptide drugs. These drugs are typically composed of amino acids linked by peptide bonds...
Biosimilars are biological products that are highly similar to an approved original biological drug (reference or brand drug) without any clinically...
Proteolysis targeting chimera (PROTAC) drugs offer a novel approach to disease treatment by leveraging the body's innate protein degradation pathways. In...
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