High-Throughput Screening
High-throughput screening (HTS) and ultra-high throughput screening (UHTS) are used in pharmaceutical and genetics research to sequence DNA, determine molecular pathways, and identify potential targets for new drugs. Using automated robotic systems, HTS machines can fill hundreds or thousands of nanowells in a microtiter plate with biological samples, add and mix reagents,...
...incubate the plate, and then read out the results, providing a multitude of experimental data points in a short time. The machines can handle several plates at once, greatly speeding up the search process.
Equipment used for HTS and UHTS includes robotic plate- and liquid-handling systems; OEM pipettes and pumps; microplate washers; microscopes for viewing experimental results; surface plasmon resonance (SPR) optical biosensors for multiplexed chips; multimode microplate readers; molecular imaging systems; multi-position reaction stations; liquid, gas and ion chromatography systems; and spectrophotometers.
Other products and services used for high-throughput screening include microtiter plates, commercially prepared stock plates, human induced pluripotent stem cells; cryogenic freezers; biosample storage units; DNA oligo service; RNAi genetic screening; LC autosamplers and column heaters/chillers; monoclonal antibodies and neural chemicals; microscopy cameras; assay kits; centrifuges; transfection reagents; and shRNA library modules.
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