Categories Molecular Biology
Mass spectrometry (MS)-based proteomics is the primary sensitive analytical tool that can be used to determine the abundance of proteins and peptides in...
O-glycosylation is another important protein glycosylation modification besides N-glycosylation. Unlike N-glycosylation, O-glycan chains are usually attached...
During the production of bioproducts, it's common to find impurities not only produced in the manufacturing process but also related to the desired products....
Dynamic light scattering (DLS), also known as photon correlation spectroscopy (PCS) or quasi-elastic light scattering (QELS), is a prevalent analytical...
Antibody drug developability analysis (drugability analysis) is a key strategy used to evaluate the development prospect of candidate antibody drug. This...
Protein content is a crucial quality control parameter in biopharmaceuticals, impacting drug efficacy, dosage, and production efficiency. Accurate...
Oligonucleotides, including DNA and RNA, have a wide range of uses in gene therapy, biological probes, and diagnosis. For example, DNA can be introduced into...
ICP-MS (inductively coupled plasma mass spectrometry) is a high-sensitivity analytical technique used to measure the concentration of metal and non-metal...
Host cell proteins (HCP) are proteins expressed by production cells and may remain in the final product during bioproduct manufacturing. HCP is a critical...
Two-dimensional fluorescence difference gel electrophoresis (2D-DIGE) is a proteomic technique for qualitatively and quantitatively comparing protein...
In the research and development and production of antibody drugs, Host Cell Protein (HCP) antibody coverage analysis is a key technology for ensuring drug...
The extinction coefficient is a unit of measurement that determines the absorption intensity of a chemical substance at a specific wavelength. The molar...
In biopharmaceutical processes, particularly for protein and antibody drugs, charge heterogeneity analysis is crucial for ensuring quality control of...
In biopharmaceutical engineering and bioproduct production, the detection and control of process-related impurities are the core of product quality...
During the biopharmaceutical manufacturing process, the residue of Host Cell Proteins (HCPs) is an unavoidable quality control issue. These residual proteins...
Host Cell Proteins (HCP) are a very important class of impurities in the biopharmaceutical process. When host cells such as E. coli, yeast, mammalian cells,...
Molecular size variability is critically important in biological research and medical applications, serving not only in diagnosis and disease prevention but...
Protein molecules are ampholytes. When the pH of the solution is adjusted so that the positive and negative charges on the protein molecules are equal, the...
Charge heterogeneity is a key attribute of biomolecules such as antibody, enzyme, and protein, affecting the molecule's stability, solubility, and biological...
Process-related impurities refer to impurities originating from the production process. Bioproducts' process-related impurities can be categorized into three...
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