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Products 11(beta)-Hydroxysteroid Dehydrogenase (Type 1) Polyclonal Antibody
| Catalogue number: | 10004303 |
| Hosts: | Rabbit |
| Applications: | Immunohistochemistry, Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | human 11(beta)-HSD1 amino acids 78-92 (CLELGAASAHYIAGT) |
| P type: | Antibodies |
| Purity: | >98% |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | 11(beta)-Hydroxysteroid dehydrogenase (Type 1) (11(beta)-HSD1) catalyzes the conversion of inactive cortisone to active cortisol in adipose tissue. mRNA and protein for this enzyme have been detected in a wide range of tissues including liver, kidney, testis, lung, heart, and colon. The enzyme's expression is developmentally regulated, suggesting its importance in regulation of glucocorticoid action during embryonic development. Over-expression of 11(beta)-HSD1 results in visceral obesity and metabolic syndrome including insulin-resistant diabetes, hyperlipidemia, and hyperphagia. Cayman |
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