

Supplier:
Cayman Chemical CompanyCat no: 13726
Acetyl Lysine Polyclonal Antibody HRP Conjugate
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SPECIFICATIONS
Catalog Number
13726
Applications
ELISA, IF, IP, WB
Hosts
Rabbit
Form
400 microL
P Type
Antibodies
Weight
0
Antigen
acetylated KLH
Storage Temp
-20
Shipping Temp
-20
Additional Info
Post-translational modifications of proteins play critical roles in the regulation and function of many known biological processes. Proteins can be post-translationally modified in many different ways, and a common post-transcriptional modification of lysine involves acetylation. The conserved amino-terminal domains of the four core histones (H2A, H2B, H3, and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs). Protein post-translational reversible lysine NE-acetylation and deacetylation have been recognized as an emerging intracellular signaling mechanism that plays critical roles in regulating gene transcription, cell-cycle progession, apoptosis, DNA repair, and cytoskeletal orgnization. The regulation of protein acetylation status is impaired in the pathologies of cancer and polyglutamine diseases, and HDACs have become promising targets for anti-cancer drugs currently in development.
Applications
ELISA, IF, IP, WB
Hosts
Rabbit
Applications
ELISA, IP, WB
Hosts
Rabbit
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