11(beta)-Hydroxysteroid Dehydrogenase (Type 2) Polyclonal Antibody

Antigen: human 11(beta)-HSD2 amino acids 25-40 (RSDLRLGRPLLAALAL) . Host: rabbit . Cross Reactivity: (+) human, mouse, and rat 11(beta)-HSD2 . Application(s): WB . 11(beta)-HSD2 plays a critical role in normal physiology in the corticosteroid regulation of sodium homeostasis and the pathophysiology of hypertension by converting active cortisol to inactive cortisone. Mutation in the gene encoding 11(beta)-HSD2 results in cortisol induction of hypertension and hypokalemia, a syndrome of apparent mineralocorticoid excess.

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SPECIFICATIONS

Catalog Number

10004549

Applications

WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies

Weight

0

Antigen

human 11.beta.-Hydroxysteroid dehydrogenase (Type 2) (11.beta.-HSD2) amino acids 25-40 (RSDLRLGRPLLAALAL)

Storage Temp

-20

Shipping Temp

-20

Additional Info

11(beta)-HSD2 plays a critical role in normal physiology in the corticosteroid regulation of sodium homeostasis and the pathophysiology of hypertension by converting active cortisol to inactive cortisone. Mutation in the gene encoding 11(beta)-HSD2 results in cortisol induction of hypertension and hypokalemia, a syndrome of apparent mineralocorticoid excess. 11(beta)-HSD2 mRNA and protein are expressed in placenta and mineralocorticoid target tissues, particularly the kidney. In mouse, expression of this enzyme is tissue-specific and developmentally regulated, indicating the importance of the enzyme in controlling glucocorticoid-mediated maturation. Cayman's 11(beta)-HSD2 polyclonal antibody can be used for western blotting and immunochemical analysis of 11(beta)-HSD2 from samples of human, rat, and mouse. The antibody detects a band at 44 kDa in tissues such as kidney and cell lines including Caco-2 cells and HT-29 cells.