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15-Lipoxygenase-1 (rabbit) Polyclonal Antiserum

Cat no: 160704

15-Lipoxygenase-1 (rabbit) Polyclonal Antiserum

Antigen: rabbit reticulocyte 15-LO . Host: sheep . Cross Reactivity: (+) rabbit, human, and mouse 15-LO-1 and 12-LO (porcine leukocyte) . Application(s): WB . 15-LO-1 catalyzes the formation of 15(S)-HETE and 13(S)-HODE from arachidonic acid and linoleic acid, respectively.

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SPECIFICATIONS

Catalog Number

160704

Applications

WB

Form

1 ea

P Type

Antibodies|Eicosanoids

Weight

0

Antigen

rabbit reticulocyte 15-LO

Storage Temp

-20

Shipping Temp

-20

Additional Info

15-Lipoxygenase-1 (15-LO-1) catalyzes the formation of 15(S)-HETE and 13(S)-HODE from arachidonic acid and linoleic acid, respectively. 15-LO-1 is a monomer with a molecular mass of approximately 75 kDa and is found primarily in reticulocytes and eosinophils. Interleukin-4 and -13 induce the expression of 15-LO-1 mRNA in human monocytes. The induction of 15-LO-1 by both agents is inhibited by IFN.gamma.. A second 15-LO, 15-LO-2, cloned from human hair roots, has been identified. 15-LO-2 exhibits approximately 40% identity to the 15-LO-1 and is expressed in prostate, lung, and cornea.

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