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Products 15-Lipoxygenase-1 (rabbit) Polyclonal Antiserum
| Catalogue number: | 160704 |
| Applications: | Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | rabbit reticulocyte 15-LO |
| P type: | Antibodies|Eicosanoids |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | 15-Lipoxygenase-1 (15-LO-1) catalyzes the formation of 15(S)-HETE and 13(S)-HODE from arachidonic acid and linoleic acid, respectively. 15-LO-1 is a monomer with a molecular mass of approximately 75 kDa and is found primarily in reticulocytes and eosinophils. Interleukin-4 and -13 induce the expression of 15-LO-1 mRNA in human monocytes. The induction of 15-LO-1 by both agents is inhibited by IFN.gamma.. A second 15-LO, 15-LO-2, cloned from human hair roots, has been identified. 15-LO-2 exhibits approximately 40% identity to the 15-LO-1 and is expressed in prostate, lung, and cornea. |
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