15-Lipoxygenase-2 Polyclonal Antibody

Antigen: human 15-LO-2 amino acids 161-179 . Host: rabbit . Cross Reactivity: (+) human 15-LO-2; (-) rabbit reticulocyte 15-LO-1 and porcine leukocyte 12-LO-1 . Application(s): WB . 15-LO-2 oxygenates C15 of arachidonic acid to produce 15(S)-HETE. Expression of 15-LO-2 appears to be restriced to prostate, lung, skin, and cornea and may play a role in the normal development of these tissues.

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SPECIFICATIONS

Catalog Number

10004454

Applications

ICC, WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies|Eicosanoids

Weight

0

Antigen

human 15-lipoxygenase-2 (15-LO-2) amino acids 161-179 (CLDEKTVEDLELNIKYSTA)

Storage Temp

-20

Shipping Temp

-20

Additional Info

Two types of 15-LO have been discovered and characterized, both of which metabolize arachidonic acid (AA) to produce 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE). 15-LO-1 oxygenates AA at both C15 and C12, whereas 15-LO-2 exclusively oxygenates C15 of AA. Human 15-LO-2 has a molecular mass of approximately 76 kDa and exhibits approximately 40% identity to the reticulocyte 15-LO-1. Expression of 15-LO-2 appears to be restricted to prostate, lung, skin, and cornea and may play a role in the normal development of these tissues. The protein levels and enzymatic activity of 15-LO-2 are both down-regulated in prostate cancer compared with normal and benign prostate tissues, implicating a possible protective role for 15-LO-2 against tumor formation. Cayman Chemical's 15-LO-2 polyclonal antibody can be used for western blot analysis for 15-LO-2 on samples of human origin. Other applications for use of this antibody have not yet been tested.