20-Hydroxyecdysone (beta-Ecdysone, Ecdysterone, BRN 1917578 , NSC 629484, Commisterone, Crustecdyson, Polypodine A, 2beta,3beta,14alpha,20R,22R,25-Hexahydroxy-5beta-cholest-7-en-6-one)

A member of the ecdysteroid family.\n Ecdysone receptor (EcR) agonist. More potent than ecdysone.\n Induces the expression of genes coding for proteins that the larva requires, and it causes chromosome puffs (sites of high expression) to form in polytene chromosomes. \nPlays a key role in insect development, cell proliferaton, growth and apoptosis by controlling gene expression involved in moulting and metamorphosis. It acts through a heterodimeric receptor comprising the ecdysone receptor and the ultraspiracle proteins (USP).\n Regulates lipolysis in insects.\n Appears in many plants mostly as a protection agent (toxins or antifeedants) against herbivorous insects. \nUsed for controlled gene expression in scientific research, agriculture and medicine. \nUsed for the development of selective insect growth regulators for use as environmentally benign insecticides. \nShows biological effects on mammalian species.\nNeurosteroid. Antiepileptic. Acts on the modulatory site of the GABAA receptor and potentiates GABAergic inhibition in rat.\nWas shown to stimulate and modulate neutrophil production.\nAntidiabetic and antiobesity. Could be used as a nutritional supplement for the prevention and treatment of obesity and obesity-associated disorders.\nMay protect PC12 cells against CoCl(2)-induced cell injury by inhibiting ROS production and modulating components of the mitochondrial apoptosis pathway. \nDoes not have potent anabolic properties, however, a muscle-specific increase is observed and genes are identified to provide an explanation for the muscle accretion.\nPotential fibrosis antagonist for renal proximal tubule cells. Acts through suppressing post-receptor signaling of TGF-beta1 and blocking the expression of Snail.\n\n\nStorage and Stability:\nShort-term Storage: +4 degrees C\nLong-term Storage: -20 degrees C\nStable for at least 2 years after receipt when stored at -20 degrees C.

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SPECIFICATIONS

Catalog Number

044439

Size

5mg

Purity

>95% (HPLC)

References

Product Reference: \n?20-hydroxyecdysone, what it can do: F. Engelmann; Science 174, 1041 (1971)\n?Relationship between 'early' and 'late' protein induced by 20-hydroxyecdysone in imaginal wing discs of Drosophila melanogaster: F.Y. Sin; Mol. Biol. Rep. 12, 7 (1987)\n?Potentiation of GABA-induced inhibition by 20-hydroxyecdysone, a neurosteroid, in cultured rat cortical neurons: S. Tsujiyama, et al.; Jpn. J. Pharmacol. 68, 133 (1995)\n?Ecdysone signaling cascade and regulation of Drosophila metamorphosis: E.H. Baehrecke, et al.; Arch. Insect Biochem. Physiol. 33, 231 (1996)\n?Antiepileptic effects of 20-hydroxyecdysone on convulsive seizures in spontaneously epileptic rats: R. Hanaya, et al.; Jpn. J. Pharmacol. 74, 331 (1997)\n?20-hydroxyecdysone as a human lymphocyte and neutrophil modulator: In vitro evaluation: D.S. Trenin & V.V. Volodin; Arch. Insect Biochem. Physiol. 41, 156 (1999)\n?Ecdysone receptors and their biological actions: L.M. Riddiford, et al.; Vitam. Horm. 60, 1 (2000) \n?Ecdysone-regulated puff genes 2000: C.S Thummel; Insect Biochem. Mol. Biol. 32, 113 (2002)\n?Ecdysone-controlled expression of transgenes: L.D. Graham; Expert Opin. Biol. Ther. 2, 525 (2002)\n?Non-genomic ecdysone effects and the invertebrate nuclear steroid hormone receptor EcR--new role for an \"old\" receptor? U. Schlattner, et al.; Mol. Cell Endocrinol. 247, 64 (2006)\n?20-Hydroxyecdysone decreases weight and hyperglycemia in a diet-induced obesity mice model: P. Kizelsztein, et al.; Am. J. Physiol. Endocrinol. Metab. 296, E433 (2009)\n?20-hydroxyecdysone reduces insect food consumption resulting in fat body lipolysis during molting and pupation: S. Wang, et al.; J. Mol. Cell Biol. 2, 128 (2010)\n?Protective effects of 20-hydroxyecdysone on CoCl(2)-induced cell injury in PC12 cells: J. Hu, et al.; J. Cell Biochem. 111, 1512 (2010)\n?Quinoa extract enriched in 20-hydroxyecdysone protects mice from diet-induced obesity and modulates adipokines expression: A.S. Foucault, et al.; Obesity 20, 270 (2012)\n?Continuous Infusion of 20-Hydroxyecdysone Increased Mass of Triceps Brachii in C57BL/6 Mice: D.M. Cheng, et al.; Phytother. Res. (Epub ahead of print) (2012)\n?20-hydroxyecdysone attenuates TGF-beta1-induced renal cellular fibrosis in proximal tubule cells: T.J. Hung, et al.; J. Diabetes Complications (Epub ahead of print) (2012)\n?

Alternative Names

beta-Ecdysone, Ecdysterone, BRN 1917578 , NSC 629484, Commisterone, Crustecdyson, Polypodine A, 2beta,3beta,14alpha,20R,22R,25-Hexahydroxy-5beta-cholest-7-en-6-one