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4-1BB ligand, 71-254aa, Recombinant, Human (4-1BBL, CD137L, TNFSF9, Tumor necrosis factor ligand superfamily member 9)

Cat no: 0004-01A

4-1BB ligand, 71-254aa, Recombinant, Human (4-1BBL, CD137L, TNFSF9, Tumor necrosis factor ligand superfamily member 9)

4-1BB ligand is a type 2 transmembrane glycoprotein belonging to the TNF superfamily. 4-1BBL is expressed by activated B cells, macrophages, dendritic cells, activated T cells, neurons and astrocytes. The interaction of 4-1BB with 4-1BBL strongly regulates immunity and has been proposed to preferentially control T cell responses based on studies in various murine models of cancer, infectious disease and autoimmune disease. Purified by using conventional chromatography.\n\nSource:\nRecombinant human 4-1BB ligand, fused to His-tag at N-terminus, was expressed in E.coli.\n\nMolecular Weight: 23.8kD (222aa)\n\nSequence of amino acids:\nMRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMRE GPELSPDDPA GLLDLRQGMF AQLVAQNVLL IDGPLSWYSD PGLAGVSLTG GLSYKEDTKE LVVAKAGVYY VFFQLELRRV VAGEGSGSVS LALHLQPLRS AAGAAALALT VDLPPASSEA RNSAFGFQGR LLHLSAGQRL\nGVHLHTEARA RHAWQLTQGA TVLGLFRVTP EIPAGLPSPR SE\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at 20 or 70 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

0004-01A

Size

100ug

Form

Supplied as liquid in 20 mM Tris-HCl buffer (pH 8.0) containing 100mM NaCl,\n20% glycerol.

Purity

(same/more than) 95% by SDS-PAGE

References

1. Lee SW., et al. (2008). Nat Immunol. 9(8):917-26, 2. Sharma RK., et al. (2009). Cancer Res. 69(10):4319-26.

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Applications

ELISA

Reactivities

Hum

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Applications

IF

Hosts

Mouse

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Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

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Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

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Applications

ELISA, FC, IHC, WB

Hosts

Mouse

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Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

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Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info

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