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5-Lipoxygenase Polyclonal Antibody

Cat no: 160402

5-Lipoxygenase Polyclonal Antibody

Antigen: human and rat amino acids 130-149; The sequence is 95% homologous to 5-LO from mouse and hamster . Host: rabbit . Cross Reactivity: (+) human, rat, mouse, hamster, and porcine 5-LO; (-) 12-LO and 15-LO . Application(s): WB . 5-LO catalyzes the formation of 5(S)-HpETE from arachidonic acid as well as its subsequent conversion to LTA4.

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SPECIFICATIONS

Catalog Number

160402

Applications

WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies|Eicosanoids

Weight

0

Antigen

human and rat amino acids 130-149 (QHRRKELETRQKQYRWMEWN); The sequence is 95% homologous to 5-LO from mouse and hamster

Storage Temp

-20

Shipping Temp

-20

Additional Info

5-Lipoxygenase (5-LO) catalyzes the formation of 5(S)-HpETE from arachidonic acid as well as its subsequent conversion to leukotriene A4. 5-LO is located in the cytosol of quiescent cells. Upon stimulation of the cell, 5-LO translocates to the nuclear membrane where it is found in association with 5-LO activating protein (FLAP) and with the 85 kDa cPLA2. 5-LO has a molecular mass of approximately 78 kDa. The enzyme is predominately expressed in peripheral blood leukocytes and also in eosinophils, mast cells, epithelial cells, and alveolar macrophages isolated from lung.

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