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Products 5-Lipoxygenase Polyclonal Antibody
| Catalogue number: | 160402 |
| Hosts: | Rabbit |
| Applications: | Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | human and rat amino acids 130-149 (QHRRKELETRQKQYRWMEWN); The sequence is 95% homologous to 5-LO from mouse and hamster |
| P type: | Antibodies|Eicosanoids |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | 5-Lipoxygenase (5-LO) catalyzes the formation of 5(S)-HpETE from arachidonic acid as well as its subsequent conversion to leukotriene A4. 5-LO is located in the cytosol of quiescent cells. Upon stimulation of the cell, 5-LO translocates to the nuclear membrane where it is found in association with 5-LO activating protein (FLAP) and with the 85 kDa cPLA2. 5-LO has a molecular mass of approximately 78 kDa. The enzyme is predominately expressed in peripheral blood leukocytes and also in eosinophils, mast cells, epithelial cells, and alveolar macrophages isolated from lung. |
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