5-OxoETE Receptor Polyclonal Antibody

Antigen: human 5-OxoETE receptor C-terminal amino acids 408-423 . Host: rabbit . Cross Reactivity: (+) human, Cos-7 (African green monkey), mouse, porcine, and rat 5-OxoETE receptor . Application(s): ICC and WB . The 5-OxoETE receptor couples to Gi/o to inhibit cyclic AMP production and to mobilize intracellular calcium, enabling chemotaxis for eosinophils and neutrophils.

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SPECIFICATIONS

Catalog Number

100025

Applications

ICC, WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies|Eicosanoids|Receptor Agonist

Weight

0

Antigen

human 5-OxoETE receptor C-terminal amino acids 408-423

Storage Temp

-20

Shipping Temp

-20

Additional Info

5-Oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OxoETE) is a potent stimulator of chemotaxis for eosinophils and neutrophils that mediates its action via a putative G-protein coupled receptor (GPCR). The 5-OxoETE receptor couples to Gi/o to inhibit cyclic AMP production and to mobilize intracellular calcium. Northern blot analysis reveals that the receptor is highly expressed on eosinophils and neutrophils, suggesting a key role in the inflammatory response. In addition, the protein can also be detected in tissues such as kidney and liver. Cayman Chemical's 5-OxoETE receptor polyclonal antibody can be used in western blot analysis (detection at 48 kDa) and immunocytochemistry. The high expression level of the receptor in leukocytes makes it the best positive control sample. When probing other tissue samples such as liver and kidney, membrane preparations or higher sensitivity detection systems may be required for visualization on immunoblot.