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Products Akt1 (Phospho-Ser473) Monoclonal Antibody (Clone 104A282)
| Catalogue number: | 13733 |
| Hosts: | Mouse |
| Applications: | Immunoprecipitation, Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | synthetic peptide from human Akt1 containing phospho-serine473 |
| P type: | Antibodies|Intracellular Signaling |
| Isotype: | IgG2k |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | Akt, protein kinase B (PKB), is a serine/threonine kinase which is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activate phosphatidylinositol 3-kinase (PI3-kinase). The major activity of Akt/PKB is to mediate cell survival. Akt/PKB is also believed to be a critical factor in the genesis of cancer, as the tumor suppressor PTEN was found to antagonise PI3 kinase and Akt/PKB kinase activity. Akt/PKB phosphorylation is critical for its activity. The major phosphorylation sites required for Akt activation have been identified as threoinine 308 and serine 473. Serine473 is phosphorylated by MAPKAP kinase 2. |
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