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Akt1 (Phospho-Ser473) Monoclonal Antibody (Clone 104A282)

Cat no: 13733

Akt1 (Phospho-Ser473) Monoclonal Antibody (Clone 104A282)

Antigen: human Akt1 containing phospho-serine473 . Host: mouse, clone 104A282 . Isotype: IgG2k . Cross Reactivity: (+) human and mouse Akt1 . Application(s): IP and WB . Akt/PKB is a serine/threonine kinase that mediates cell survival and is thought to be a critical factor in the genesis of cancer. The major phosphorylation sites required for activation are Thr308 and Ser473.

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SPECIFICATIONS

Catalog Number

13733

Applications

IP, WB

Hosts

Mouse

Form

1 ea

P Type

Antibodies|Intracellular Signaling

Weight

0

Antigen

synthetic peptide from human Akt1 containing phospho-serine473

Isotype

IgG2k

Storage Temp

-20

Shipping Temp

-20

Additional Info

Akt, protein kinase B (PKB), is a serine/threonine kinase which is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activate phosphatidylinositol 3-kinase (PI3-kinase). The major activity of Akt/PKB is to mediate cell survival. Akt/PKB is also believed to be a critical factor in the genesis of cancer, as the tumor suppressor PTEN was found to antagonise PI3 kinase and Akt/PKB kinase activity. Akt/PKB phosphorylation is critical for its activity. The major phosphorylation sites required for Akt activation have been identified as threoinine 308 and serine 473. Serine473 is phosphorylated by MAPKAP kinase 2.

SUPPLIER INFO

Cayman Chemical Company

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