Allosteric Akt (PKB) inhibitors used in synergistic combination therapy for the treatment of cancer.
Melting Point:
256-258C
Solubility:
DMSO, Methanol (sparingly)
Method for Determining Identity:
Proton NMR (DMSO-d6) Spectroscopic and Mass Spectrometric Analysis
TLC Conditions:
SiO2; Dichloromethane: Methanol: NH4OH; 9:1:0.1; Visualized with UV and AMCS; SIngle spot. Rf=0.6
Storage and Stability:
May be stored at RT for short-term only. Long-term storage is recommended at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.