Home  >  Products  >  AMP Activated Protein Kinase alpha2 (AMPK alpha-2 Chain, AMPK Subunit alpha-2, AMPK a2, 5'-AMP-activated Protein Kinase Catalytic Subunit alpha-2, AMPK2, PRKAA2, PRKAA)
AMP Activated Protein Kinase alpha2 (AMPK alpha-2 Chain, AMPK Subunit alpha-2, AMPK a2, 5'-AMP-activated Protein Kinase Catalytic Subunit alpha-2, AMPK2, PRKAA2, PRKAA)

AMP Activated Protein Kinase alpha2 (AMPK alpha-2 Chain, AMPK Subunit alpha-2, AMPK a2, 5'-AMP-activated Protein Kinase Catalytic Subunit alpha-2, AMPK2, PRKAA2, PRKAA)

Cat no: A1475-02M

Supplier: United States Biological
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AMPK2 is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. Applications: Suitable for use in ELISA and Western Blot. Other applications have not been tested. Recommended Dilutions: ELISA: 0.25ug/ml Western Blot: 0.5-2.5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A1475-02M
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.09% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by ammonium sulfate precipitation.
Alternative names: EC=2.7.11.1, Protein Kinase AMP-activated alpha 2 Catalytic Subunit
References: 1.Wyatt,C.N., J. Biol. Chem. 282 (11), 8092-8098 (2007) 2.Cheung,S.T., Neoplasia 8 (9), 696-701 (2006) 3.Lee-Young,R.S., Am. J. Physiol. Endocrinol. Metab. 291 (3), E566-E573 (2006) 4.Gregory,S.G., Nature 441 (7091), 315-321 (2006)
Additional info: Recognizes human AMPK2.

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