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AMPK1 (5'-AMP-activated Protein Kinase Catalytic Subunit alpha-1, AMPK Subunit alpha-1, PRKAA1)

AMPK1 (5'-AMP-activated Protein Kinase Catalytic Subunit alpha-1, AMPK Subunit alpha-1, PRKAA1)

Cat no: A1475-06J

Supplier: United States Biological
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AMPK1 acts as a central regulator of cellular metabolism for which it serves as an energy sensor, the enzyme is activated by a reduction of ATP/AMP levels, changes in intracellular calcium, and other forms of stress, including ischemia and hypoxia. The protein is at the center of control for a large number of metabolic reactions, thereby playing a crucial role in Type 2 diabetes and other human diseases The protein is also crucial for cell polarity and mitosis as confirmed by recent studies. AMPK1 is thus a key energy sensor, known to regulate energy metabolism in diverse cell types. Structurally heterotrimeric AMPK contains a catalytic alpha-subunit, encoded by two genes (alpha1 and alpha2). The protein is usually present in the nucleus and cytoplasm. Human AMPK1 gene is mapped to chromosomal region 5p12. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Immunohistochemistry (paraffin): 1:50-1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A1475-06J
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Mohamed, K. et al. Am. J. Physiol. Cell. Physiol. 293:C1427-C1436 (2007).
Additional info: Recognizes human AMPK1. Species Crossreactivity: mouse and rat.

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