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Amyloid P Component, Serum (SAP, APCS, PTX2, mature chain 204aa, chromosome 1q21-23)

Cat no: A2275-88P

Amyloid P Component, Serum (SAP, APCS, PTX2, mature chain 204aa, chromosome 1q21-23)

Serum Amyloid P component (SAP) is a non-fibrillar plasma glycoprotein that belongs to the pentraxin family. It is universally found in amyloid deposits (such as senile plaque and neurofibrially tangles in Alzheimers patients), and this is probably due to its specific calcium-dependent binding to motifs, which are present on all types of amyloid fibrils. SAP is also found to prevent fibrillar breakdown by enzymes and it is believed that it helps maintains stability of the amyloid deposits. It has been shown that SAP binds monocytes with high avidity, but does not bind to erythrocytes, NK cells, T-lymphocytes, or B-lymphocytes. SAP production can be induced by exposure to IL-1, IL-6, and IFN-beta. SAP levels in CSF can be useful for assessing cognitive impairment in AD patients. \n\nApplications:\nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilutions:\nELISA: 0.05-0.2ug/ml \nWestern Blot: 0.1-1.0ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

A2275-88P

Size

40ug

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

Additional Info

Recognizes human serum amyloid P component. Species Crossreactivity: mouse

Read more on Supplier website

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

More info

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

More info

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

More info
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