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Amyloid Precursor Protein (APP, Amyloid beta (A4) Precursor Protein)

Cat no: A2275-69V


Supplier: United States Biological
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Amyloid Precursor Protein IS a 130kD member of the APP family, expressed in adult brain. It is a cell surface kinesin I membrane receptor which regulates the axonal transport of beta-secretase and presenilin 1.In Alzheimer's disease processing of APP by beta-secretase gives rise to amyloidogenic 42 AA beta amyloid protein that is found in senile plaques and vessels. APP binds components of the extracellular matrix such as heparin and collagen I and IV, regulating neurite growth and is also involved in neuronal adhesion, cell mobility and axonogenesis. Through it
Catalogue number: A2275-69V
Reactivities: Human
Hosts: Goat
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 100ul
Form: Supplied as a liquid, 0.09% sodium azide
P type: Pab
Isotype: IgG
Purity: Serum
Alternative names: A4, AAA, ABETA, ABPP, AD1, Alzheimer Disease Amyloid Protein, Amyloid beta (A4) Precursor Protein (Peptidase Nexin-II, Alzheimer Disease), Amyloid beta A4 Protein Precursor, APPI, Cerebral Vascular Amyloid Peptide, CTFgamma, CVAP, PN2, PN-II, PreA4, Protease Nexin-II
References: 1. Venezia, V. (2007) Amyloid precursor protein and presenilin involvement in cell signaling. Neurodegener. Dis. 4:101-11.
Additional info: Recognizes human Amyloid Precursor Protein.

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