Androgen Receptor (AR)

The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor which is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus. The androgen receptor is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor. The main function of the androgen receptor is as a DNA binding transcription factor which regulates gene expression; however, the androgen receptor has other functions as well. Androgen regulated genes are critical for the development and maintenance of the male sexual phenotype.\n\nApplications:\nSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:10000\nWestern Blot: 1:1000-1:2000\nImmunohistochemistry (Paraffin): 1:10,000\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

A2281-06G

Size

100ul

Applications

ELISA, IHC, WB

Hosts

Mouse

Reactivities

Hum, Mouse

Form

Supplied as liquid, 0.04% sodium azide.

P Type

Mab

Purity

Ascites

Isotype

IgG1

References

1. Chin Med J (Engl). 2009 Nov 20;122(22):2779-83, 2. Taiwan J Obstet Gynecol. 2009 Sep;48(3):262-7, 3. Prostate. 2008 Mar 1; 68(4):453-61, 4. Cancer Res. 2007 May 15; 67(10):4630-7.

Additional Info

Recognizes human Androgen Receptor (AR) at 110kD.