Angiotensin Converting Enzyme (ACE)

Cat no: A2295-01B3

Supplier: United States Biological

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Additional Information

Angiotensin-converting enzyme (ACE) is a zinc-containing dipeptidyl carboxypeptidase anchored in the plasma membrane with a carboxy-terminal hydrophobic domain (1, 2). ACE has a critical role in cardiovascular function because it catalyses the conversion of angiotensin I to the physiologically active vasopressor octapeptide angiotensin II, which controls fluid-electrolyte balance and systemic blood pressure (3, 4). Inhibitors of ACE are a first line of therapy for hypertension, heart failure, myocardial infarction and diabetic nephropathy (4). ACE also plays a critical role in the circulating or endocrine renin-angiotensin system (RAS) as well as the local regulation that exists in tissues such as the myocardium and skeletal muscle (5). Applications: Suitable for use in Western Blot, Immunohistochemistry and Flow Cytometry. Other applications not tested. Recommended Dilutions: Western Blot: 1:500 -1000 Immunohistochemistry: 1:100-250 Flow Cytometry: 1:30 Optimal dilution determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.

Catalogue number:	A2295-01B3
Reactivities:	Human, Mouse
Hosts:	Rabbit
Applications:	Flow Cytometry, Immunohistochemistry, Western Blot
Size:	100ul
Form:	Supplied as liquid in 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
P type:	Mab
Isotype:	IgG
Purity:	Serum
References:	1. Ehlers MR, et al. Proc Natl Acad Sci U S A. 86(20): 7741-5, 1989 2. Sugimura K, et al. Biochem Biophys Res Commun. 247(2): 466-72, 1998 3. Rieder MJ, et al. Nat Genet. 22(1): 59-62, 1999. 4. Natesh R, et al. Nature. 421(6922): 551-4, 2003. 5. Natesh R, et al. Biochemistry. 43(27): 8718-24, 2004
Additional info:	Recognizes human ACE. Species Crossreactivity: mouse

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Angiotensin Converting Enzyme (ACE)

Cat no: A2295-01B3

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