ANGPTL3 demonstrates pro-angiogenic effects by binding integrin (alpha)v(beta)3, which induces endothelial cell migration and adhesion. It also dually inhibits the catalytic activities of lipoprotein lipase, which catalyzes the hydrolysis of triglycerides, and endothelial lipase, which hydrolyzes HDL phospholipids. Human ANGPTL3 plasma concentrations positively correlate with plasma HDL cholesterol and HDL phospholipid levels. Cayman's Human ANGPTL3 EIA Kit is an immunometric assay that can be used to measure ANGPTL3 in human serum, plasma, or cell culture supernatants.
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