Mouse anti-5-Hydroxytryptamine monoclonal antibody for IHC, FuncS. Serotonin(5-hydroxytryptamine, or 5-HT) is a monoamine neurotransmitter synthesised inserotonergic neurons in the central nervous system and enterochromaffin cellsin the gastrointestinal tract. Serotonin plays an important part in thebiochemistry of depression, migraine, bipolar disorder and anxiety. It isalso believed to be influential on sexuality and appetite. 5-HT is generallythought not to be released from synaptic terminal buttons in the manner ofclassical neurotransmission but from serotonergic varacosities into the extraneuronal space. From here it is free to diffuse over a relatively largeregion of space ( 20µm) and activate 5-HT receptors located on thedendrites, cell bodies and presynaptic terminals of adjacent neurons.Serotonergic action is terminated primarily via uptake of 5-HT from thesynapse. This is through the specific monoamine transporter for 5-HT, 5-HTreuptake transporter, on the presynaptic neuron. The pharmacology of 5-HT isextremely complex, with its actions being mediated by a large and diverserange of 5-HT receptors.
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