anti-CD4 Molecule (CD4) antibody: The CD43 antigen (synonyms: leukosialin, gp95, sialophorin, leucocyte sialoglycoprotein) is an integral typ-1 membrane protein with molecular weight of about 95-110 kDa. It belongs to the family of cell surface mucins and functions in T-cell immunity and cell-cell interactions. CD43 is expressed on most T-cells, on activated B-cells, NK-cells, granulocytes, macrophages, and megakaryocytes. Resting B-cells are CD43 negative. Immunohistochemistry (IHC) is a complex technique in which immunological and histological detection methods are combined. In general, the manipulation and processing of tissues before immunostaining, especially different types of tissue fixation and embedding, as well as the nature of the tissues themselves may cause inconsistent results (Nadji and Morales, 1983). Endogenous pseudoperoxidase and peroxidase activity or endogenous biotin and alkaline phosphatase activity can cause non-specific staining results depending on the detection system used. Tissues that contain Hepatitis B surface antigen (HBsAg) can produce false positives when using HRP detection systems (Omata et al, 1980). Insufficient contrast staining and/or improper mounting of the sample may influence the interpretation of results.
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