anti-TCRgd antibody: The antibody detects: Chicken TCR MAb TCR1 precipitates a heterodimer of Mr 90 kDa (two bands of Mr 40 kDa and 50 kDa upon reduction) on chicken peripheral blood T cells. Deglycosylation of the heterodimer yields two polypeptides of Mr 35 kDa and 32 kDa from TCR1 precipitates. Unlike human and mouse, in which cells comprise a minor subset of T lymphocytes in the circulation, the chicken has a relatively large subset of T cells. The frequency of TCR cells is usually 20-25 % of the total blood T cells, but may reach approximately 50 % in chickens of 6 months of age. The majority of TCR+ cells in the thymus and blood are CD4-CD8-, although a small subset of them may express CD8 or CD4 coreceptors. However, when the TCR+ cells migrate into the spleen and intestine, most of them begin to express CD8. Although the biological function of T cells is unclear, they are clearly capable of cytotoxic activity in vitro. The CD8+ T cells may also be involved in down-regulation of the immune response. They cannot, however, induce a graft-vs-host (GVH) reactions.
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