Apaf-1 Polyclonal Antibody

Antigen: human Apaf-1 amino acids 12-28; the sequence of the peptide is identical between human and mouse . Host: rabbit . Cross Reactivity: (+) human and mouse Apaf-1 . Application(s): WB . Apaf-1 binds to cytochrome c (Apaf-2) and caspase-9 (Apaf-3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3, one of the key proteases responsible for the proteolytic cleavage of many key proteins in apoptosis. It can also associate with caspase-4 and -8.

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SPECIFICATIONS

Catalog Number

160780

Applications

WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies|Intracellular Signaling

Weight

0

Antigen

human Apaf-1 amino acids 12-28 (HREALEKDIKTSYIMDHC); the sequence of the peptide is identical between human and mouse{6894,6873}

Storage Temp

4

Shipping Temp

4

Additional Info

Apoptosis is related to many diseases and is induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified recently from human and mouse and designated Apaf-1 (apoptosis protease-activating factor 1) Apaf-1 binds to cytochrome c (Apaf-2) and caspase-9 (Apaf-3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3, one of the key proteases responsible for the proteolytic cleavage of many key proteins in apoptosis. Apaf-1 can also associate with caspase-4 and caspase-8. Apaf-1 is ubiquitously expressed in human tissues.