ARAP2 Polyclonal Antibody

Antigen: human ARAP2 within the region of amino acids 1,670-1,720 . Host: rabbit . Cross Reactivity: (+) human ARAP2 . Application(s): IHC and WB . ARAP2 is a PIP3-dependent GTPase-activating protein that binds to RhoA-GTP, and modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. ARAP2 associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics.

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SPECIFICATIONS

Catalog Number

13495

Applications

IHC, WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies|Intracellular Signaling

Weight

0

Antigen

synthetic peptide from human ARAP2 within the region of amino acids 1,670-1,720

Storage Temp

-20

Shipping Temp

-20

Additional Info

ARAP2, also known as centaurin-d-1, is a protein with ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. A phosphatidylinositol-3,4,5-trisphosphate (PtdIns-(3,4,5)-P3)-dependent GTPase-activating protein, ARAP2, binds to RhoA-GTP, but lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. It modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Usually ARAP2 is activated by PtdIns-(3,4,5)-P3 binding and can be activated by PtdIns-(3,4)-P2 binding, although with lower efficiency. ARAP2 associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. It is usually detected in brain, thymus, lymph node, thyroid, spinal cord, trachea, heart, skeletal muscle, spleen, kidney, liver, placenta, lung, and peripheral blood leukocytes.