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ARC Polyclonal Antibody

Cat no: 160737

ARC Polyclonal Antibody

Antigen: human ARC amino acids 191-208 . Host: rabbit . Cross Reactivity: (+) human and mouse ARC . Application(s): IP and WB . ARC interacts with caspase-2 and -8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1, and DR3.

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SPECIFICATIONS

Catalog Number

160737

Applications

IP, WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies|Intracellular Signaling

Weight

0

Antigen

human ARC amino acids 191-208 (PDPEPEPDFEERDESEDS){7140}

Storage Temp

-20

Shipping Temp

-20

Additional Info

Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD domain-containing cell death regulators included RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD. ARC interacts with caspase-2 and -8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1 and DR3. The mRNA for ARC is expressed primarily in skeletal muscle and cardiac tissues.

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