ARHGDIB, CT (ARHGDIB, GDIA2, GDID4, RAP1GN1, Rho GDP-dissociation inhibitor 2, Ly-GDI, Rho-GDI beta)

Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).\n\nApplications:\nSuitable for use in Western Blot, Immunohistochemistry, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\nImmunohistochemistry: 1:10-50\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

032045

Size

200ul

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Niu, H., et al. Oncol. Rep. 24(2):465-471(2010)\nZhen, H., et al. Int. J. Gynecol. Cancer 20(3):316-322(2010)\nGuey, L.T., et al. Eur. Urol. 57(2):283-292(2010)\nSaid, N., et al. Cancer Metastasis Rev. 28 (3-4), 327-333 (2009) :\nHosgood, H.D. III, et al. Respir Med 103(12):1866-1870(2009)

Additional Info

Human

Alternative Names

ARHGDIB, GDIA2, GDID4, RAP1GN1, Rho GDP-dissociation inhibitor 2, Ly-GDI, Rho-GDI beta