ATF2 (Phospho-Ser490,498) Polyclonal Antibody

Antigen: synthetic phosphopeptide corresponding to amino acid residues surrounding phospho-Ser490,498 of human ATF2 . Host: rabbit . Cross-reactivity: (+) human ATF2; expected to react with rat ATF2 . Applications: WB and IHC (frozen sections) . ATF2 binds to both AP-1 and CRE DNA response elements and is a member of the ATF/CREB family of leucine zipper proteins. It has been implicated in the transcriptional regulation of a number of genes including cytokines, cell cycle control, and apoptosis.

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SPECIFICATIONS

Catalog Number

10009410

Applications

IHC, WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies|Transcription Factors|Intracellular Signaling

Weight

0

Antigen

synthetic phosphopeptide corresponding to amino acid residues surrounding phospho-Ser490,498 of human ATF2

Storage Temp

-20

Shipping Temp

-20

Additional Info

The activating transcription factor 2 (ATF2; also called CRE-BP1) binds to both AP-1 and CRE DNA response elements and is a member of the ATF/CREB family of leucine zipper proteins. ATF2 has been implicated in the transcriptional regulation of a number of genes including cytokines, cell cycle control, and apoptosis. Various forms of cellular stress, including inflammatory cytokines and UV irradiation, stimulate the transcriptional activity of ATF2. Stress induced ATF-dependent transcription is dependent on phosphorylation of ATF. Serine 490 and serine 498 are novel phosphorylation sites on ATF that have recently been identified. ATF2 is particularly abundant in the brain and the ATF2 family of transcription factors is considered an important substrate of signals upstream of the activation of genes associated with neuronal growth and differentiation. ATF expression has also been linked to depression in humans.