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BACE1 (485-501) (Beta-site APP Cleaving Enzyme)

BACE1 (485-501) (Beta-site APP Cleaving Enzyme)

Cat no: B0002-91Q

Supplier: United States Biological
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b-secretase, also called BACE (b-site of APP cleaving enzyme), is an aspartic-acid protease important in the pathogenesis of Alzheimer's disease, and in the formation of myelin sheaths in peripheral nerve cells. BACE1, also known as memapsin-2, is the major b-secretase for generation of the 40 or 42 amino acid-long b-amyloid peptides that aggregate in the brain of Alzheimer's patients. Extracellular cleavage of APP by BACE1 releases a soluble extracellular fragment and is followed by APP cleavage within its transmembrane domain by g-secretase. The second cleavage releases the intracellular domain of APP and b-amyloid. The immature form of BACE1 contains an N-terminal signal sequence (residues 1
Catalogue number: B0002-91Q
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 40ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 30% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. H. Cai et al. (2001) Nature Neuroscience, 4 (3):233-4. 2. X Hu et al. (2006) Nature Neuroscience, 9 (12):1520-5.
Additional info: Recognizes human BACE1. Species sequence homology: mouse, rat and bovine

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