Home  >  Products  >  BACE1 (Beta-site Amyloid Precursor Protein Cleaving Enzyme 1, Beta-site APP Cleaving Enzyme 1, BACE, Aspartyl Protease 2, Asp 2, ASP2, Beta-secretase 1, FLJ90568, HSPC104, KIAA1149, Memapsin-2, Membrane-associated Aspartic Protease 2)
BACE1 (Beta-site Amyloid Precursor Protein Cleaving Enzyme 1, Beta-site APP Cleaving Enzyme 1, BACE, Aspartyl Protease 2, Asp 2, ASP2, Beta-secretase 1, FLJ90568, HSPC104, KIAA1149, Memapsin-2, Membrane-associated Aspartic Protease 2)

BACE1 (Beta-site Amyloid Precursor Protein Cleaving Enzyme 1, Beta-site APP Cleaving Enzyme 1, BACE, Aspartyl Protease 2, Asp 2, ASP2, Beta-secretase 1, FLJ90568, HSPC104, KIAA1149, Memapsin-2, Membrane-associated Aspartic Protease 2)

Cat no: B0002-88K

Supplier: United States Biological
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Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Four transcript variants encoding different isoforms have been described for this gene. Bace 1 is responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 3ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human brain, Alzheimers Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: B0002-88K
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 50ug
Form: Supplied as a liquid in PBS, 0.1% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: Beta-site APP-cleaving Enzyme 1, EC=3.4.23.46
References: 1. Bioorg Med Chem Lett 2006 Oct. : Design of potent inhibitors of human beta-secretase. Part 2. Freskos JN, Fobian YM, Benson TE, Moon JB, Bienkowski MJ, Brown DL, Emmons TL, Heintz R, Laborde A, McDonald JJ, Mischke BV, Molyneaux JM, Mullins PB, Bryan Prince D, Paddock DJ, Tomasselli AG, and Winterrowd G. 2. Neurodegener Dis 2006 . 3:270-4 Amyloid Precursor Protein and BACE Function as Oligomers. Multhaup G. 3. Neurodegener Dis 2006 . 3:262-9 Ectodomain shedding of the amyloid precursor protein: cellular control mechanisms and novel modifiers. Lichtenthaler SF. 4. Neurodegener Dis 2006 . 3:247-54 Control of Amyloid-beta-Peptide Generation by Subcellular Trafficking of the beta-Amyloid Precursor Protein and beta-Secretase. Walter J. 5. Neurodegener Dis 2006 . 3:218-26 Subcellular trafficking of the amyloid precursor protein gene family and its pathogenic role in Alzheimer's disease. Kins S, Lauther N, Szodorai A, and Beyreuther K.
Additional info: Recognizes human BACE1/ASP2. Species Sequence Homology: rat.

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