Bafilomycin D (Tubaymycin, Antibiotic 3D5)

Bafilomycin D shares the same mode of action as bafilomycin A1 which has been the analog of choice in cell biology studies of the role of ATPase. Bafilomycin D contains the ring opened side chain and is a much more stable analog of bafilomycin A1. In-house data demonstrate that bafilomycin D is also a much more selective inhibitor of mammalian cells than bafilomycin A which exhibits a broad profile against tumor cells, fungi and nematodes. Limited availability has restricted a more in depth investigation of this metabolite.\n\nSource:\nBafilomycin D\n\nMolecular Weight:\n~604.8\n\nSolubility:\nSoluble in ethanol, methanol, DMF or DMSO.\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with ethanol, methanol, DMF or DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

B0003-73

Size

1mg

Form

Supplied as a white solid.

Purity

(same/more than) 95% by HPLC

References

1. The structure of novel insecticidal macrolides: bafilomycin D and E, and oxhygrolidin. Kretschmer, A., et al., Agric. Biol. Chem. 49: 2509 (1985). 2. Bafilolides, potent Inhibitors of the motility and development of the free-living stages of parasitic nematodes. Lacey, E., et al., Int. J. Parasitol. 25: 349 (1995).

Alternative Names

Tubaymycin, Antibiotic 3D5