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Basic Hair Keratin 1 (ghHb1, ghHKb1, Hair Keratin K2.9, HB1, Hb-1, hHAKB2-1, Keratin 81, Keratin-81, K81, KRT81, Keratin Type II Cuticular Hb1, KRTHB1, Metastatic Lymph Node 137 Gene Protein, MLN 137, MLN137, Type II Hair Keratin Hb1, Type-II Keratin Kb21

Cat no: B0130-05-HRP

Basic Hair Keratin 1 (ghHb1, ghHKb1, Hair Keratin K2.9, HB1, Hb-1, hHAKB2-1, Keratin 81, Keratin-81, K81, KRT81, Keratin Type II Cuticular Hb1, KRTHB1, Metastatic Lymph Node 137 Gene Protein, MLN 137, MLN137, Type II Hair Keratin Hb1, Type-II Keratin Kb21

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix. [provided by RefSeq]\n\nApplications:\nSuitable for use in ELISA, Immunofluorescence, Immunohistochemistry (paraffin), and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1ug/ml-3ng/ml\nWestern Blot: 1:500-1:1,000\nImmunohistochemistry (paraffin): 1.5ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze horseradish peroxidase conjugates which could result in a substantial loss of enzymatic activity. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

B0130-05-HRP

Size

100ul

Applications

ELISA, IF, IHC, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2. No preservative added (Azide free). Conjugated to HRP.

P Type

Mab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG2b

Additional Info

Recognizes human KRTHB1.

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