Batimastat (BB-94)

Cat no: B0130-90

Supplier: United States Biological

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Potent, broad spectrum matrix metalloprotease (MMP) inhibitor (IC?? values are 3, 4, 4, 6 and 20 nM for MMP -1, -2, -9, -7 and -3 respectively). Exhibits antiproliferative, anti-invasive and antimetastatic activity in human ovarian carcinoma xenografts in vivo. Solubility: DMSO (~100mM) Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Catalogue number:	B0130-90
Size:	1mg
Form:	Supplied as a white solid
Purity:	~98% (HPLC)
Alternative names:	(2R,3S)-N4-Hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide
References:	1. Davies et al (1993) A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts. Cancer Res. 53 2087. 2. Wang et al (1994) Matrix metalloproteinase inhibitor BB-94 (Batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice. Cancer Res. 54 4726. 3. Kohn and Liotta (1995) Molecular insights into cancer invasion: strategies for prevention and intervention. Cancer Res. 55 1856.

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Batimastat (BB-94)

Cat no: B0130-90

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