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Products (beta)-Catenin (Phospho-Ser33,37) Polyclonal Antibody
| Catalogue number: | 10009180 |
| Hosts: | Rabbit |
| Applications: | Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser33,37 of human .beta.-catenin |
| P type: | Antibodies|Phospholipase|Intracellular Signaling |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | .beta.-Catenin is a central component of the cadherin cell adhesion complex and plays an essential role in neural development in the Wingless/Wnt signaling pathway. The role of .beta.-catenin in these processes is thought to be regulated by the sequential phosphorylation of Ser29, Ser33, Ser37, and Thr41 by glycogen synthase kinase 3.beta. (GSK3.beta.). This hyperphosphorylation promotes the ubiquitylation and targeted destruction of .beta.-catenin. Mutations in components of this phosphorylation-regulated process that prevent .beta.-catenin hyperphosphorylation by GSK3.beta. are strongly associated with cancers. |
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