

Supplier:
Cayman Chemical CompanyCat no: 10011385
Bim/BOD (IN) Polyclonal Antibody
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SPECIFICATIONS
Catalog Number
10011385
Applications
IHC, WB
Hosts
Rabbit
Form
100 microg
P Type
Antibodies|Intracellular Signaling
Weight
23
Antigen
internal central human Bim amino acids
Storage Temp
-20
Shipping Temp
-20
Additional Info
Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bim/BOD is a group of three splice variants, BimEL, BimL and BimS, with apparent molecular masses of ~23, 16, and 13 kDa, respectively. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bim or BOD in human, mouse, and rat. Bim/BOD interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Bim/BOD induces apoptosis. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines.
Applications
ELISA, IF, IP, WB
Hosts
Rabbit
Applications
ELISA, IP, WB
Hosts
Rabbit
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