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Bim/BOD (IN) Polyclonal Antibody

Cat no: 10011385

Bim/BOD (IN) Polyclonal Antibody

Antigen: internal central human Bim amino acids . Host: rabbit . Cross Reactivity: (+) human, mouse, and rat Bim/BOD (IN) . Applications: IHC and WB . Bim/BOD interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, -xL, and -w and induces apoptosis.

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SPECIFICATIONS

Catalog Number

10011385

Applications

IHC, WB

Hosts

Rabbit

Form

100 microg

P Type

Antibodies|Intracellular Signaling

Weight

23

Antigen

internal central human Bim amino acids

Storage Temp

-20

Shipping Temp

-20

Additional Info

Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bim/BOD is a group of three splice variants, BimEL, BimL and BimS, with apparent molecular masses of ~23, 16, and 13 kDa, respectively. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bim or BOD in human, mouse, and rat. Bim/BOD interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Bim/BOD induces apoptosis. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines.

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