BIN1 (AMPHL, AMPH2, , SH3P9, amphiphysin II, Amphiphysin-like protein, Box-dependent myc-interacting protein 1, Bridging integrator 1)

BIN1 (AMPH2) is a novel human gene product with features of a tumor suppressor protein. BIN1 gene to chromosome 2q14. Loss of BIN1 expression appears to be a frequent aberration in human hepatocellular carcinomas . mutations in BIN1 cause centronuclear myopathy by interfering with remodeling of T tubules and/or endocytic membranes, and that the functional interaction between BIN1 and DNM2 is necessary for normal muscle function and positioning of nuclei.\n\nUniProt Number:\nHuman(O00499), Mouse(O08539), Rat(O08839)\n\nGene ID:\nBIN1\n\nApplications:\nSuitable for use in Western Blot, Immunohistochemistry (Frozen), and Immunocytochemistry.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Handling:\nStore at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term.\nAvoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

144238

Size

100ug

Applications

ICC, IHC, WB

Hosts

Mouse

Reactivities

Hum, Mouse, Rat

Form

Ascites, supplied as a lyophilized powder. Reconstitution: 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.

P Type

Mab

Isotype

IgG2b

References

1. Sakamuro, D.; Elliott, K. J.; Wechsler-Reya, R.; Prendergast, G. C. : BIN1 is a novel MYC-interacting protein with features of a tumour suppressor. Nature Genet. 14: 69-77, 1996.\n2. Negorev, D.; Riethman, H.; Wechsler-Reya, R.; Sakamuro, D.; Prendergast, G. C.; Simon, D. : The Bin1 gene localizes to human chromosome 2q14 by PCR analysis of somatic cell hybrids and fluorescence in situ hybridization. Genomics 33: 329-331, 1996.\n3. Nicot, A.-S.; Toussaiant, A.; Tosch, V.; Kretz, C.; Wallgren-Petterson, C.; Iwarsson, E.; Kingston, H.; Garnier, J.-M.; Biancalana, V.; Oldfors, A.; Mandel, J.-L.; Laporte, J. : Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy. (Letter) Nature Genet. 39: 1134-1139, 2007.

Additional Info

Recognizes human, mouse and rat BIN1. No crossreactivity with other proteins.