Bmp6, NT (Bone Morphogenetic Protein 6, BMP-6, VG-1-related Protein, VG-1-R, VGR-1, VGR) (AP)

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, Bmp6 has a proposed role in early development. In addition, the fact that BMP6 is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.\n\nApplications: \nSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-1:500\nImmunohistochemistry: 1:10-1:50\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Do not freeze alkaline phosphatase conjugates which could result in a substantial loss of enzymatic activity. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

B2553-30A-AP

Size

200ul

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Alkaline Phosphatase.

P Type

Pab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG

References

1.Lories, R.J., et al., Arthritis Rheum. 48(10):2807-2818 (2003). 2.Bobacz, K., et al., Arthritis Rheum. 48(9):2501-2508 (2003). 3.Tamada, H., et al., Biochim. Biophys. Acta 1395(3):247-251 (1998). 4.Rickard, D.J., et al., J. Clin. Invest. 101(2):413-422 (1998). 5.Olavesen, M.G., et al., Genomics 46(2):303-306 (1997).

Additional Info

Recognizes human Bmp6 at ~57kD.