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Products BRD4/HUNK1 Polyclonal Antibody
| Catalogue number: | 13497 |
| Hosts: | Rabbit |
| Applications: | Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | synthetic peptide from human Brd4 within the region of amino acids 150-200 |
| P type: | Antibodies |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | BRD4, a ubiquitously expressed nuclear phosphoprotein, is a member of the BET protein family. It is a human homolog of mouse mCAP and consists of 2 N-terminal bromodomains, a central ET-domain, and several kinase-like motifs in its N-terminus. It is expressed as 2 isoforms; the longer variant has a C-terminal region with proline and glutamine-rich domains. BRD4 is a chromatin-binding protein whos expression is induced in response to growth stimuli. BRD4 acts at different stages of the cell cycle by interacting with proteins including RFC and SPA-1 and regulates cell growth. It also has a role in regulating chromosomal dynamics during mitosis. BRD4 functions as a cellular target for E2 protein of papillomavirus. |
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