C-Reactive Protein (human) EIA Kit

CRP is a 224 amino acid protein that is synthesized primarily by hepatocytes, and to a lesser extent adipocytes. CRP plasma levels increase ~1,000-fold in response to acute and chronic inflammatory conditions, making it a useful gauge of inflammation in a wide range of physiological and pathological conditions. High plasma CRP concentrations (>3 microg/ml) are associated with an increased risk for atherosclerosis. Cayman's CRP (human) EIA is a sensitive immunometric assay which can be used to measure CRP in plasma without prior sample purification. The standard curve spans the range of 0-3,000 pg/ml with a limit of detection of approximately 50 pg/ml.

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SPECIFICATIONS

Catalog Number

10011236

Form

96 Well

P Type

Assay Kits

Weight

0

Storage Temp

4

Shipping Temp

4

Additional Info

C-Reactive Protein (CRP) is a 224 amino acid protein that is synthesized primarily by hepatocytes, and to a lesser extent adipocytes. CRP plasma levels increase ~1,000-fold in response to acute and chronic inflammatory conditions, making it a useful gauge of inflammation in a wide range of physiological and pathological conditions. Normal levels of serum CRP (0.64 microg/ml) do not differ between healthy adult men and women, but tend to increase slightly with age. High plasma CRP concentrations (>3 microg/ml) are associated with an increased risk for atherosclerosis. CRP has been implicated as a contributor to atherogenesis by modulating endothelial function, stimulating coagulation, inducing the expression of ICAM-1, VCAM-1, and E-selectin, mediating uptake of LDL into macrophages, and destabilizing plaques. In addition, CRP can bind in a calcium-dependent manner to phosphocholine on microbes, act as a ligand for specific receptors on phagocytic leukocytes, mediate activation of monocytes and macrophages via IL-6, TNF-.alpha. and other cytokines, and assist in the complement pathway. Cayman