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CABIN1 (Calcineurin Binding Protein CABIN1)

Cat no: 137418

CABIN1 (Calcineurin Binding Protein CABIN1)

Calcineurin binding protein CABIN1 was originally identified as an inhibitor of the calcium-dependent serine/threonine phosphatase, calcineurin. CABIN1 inhibits calcineurin signaling in T cells, regulating T cell receptor (TCR) signaling, transcription, and apoptosis (1-4). CABIN1 represses myocyte enhancer factor 2 (MEF2)-mediated transcription by recruiting chromatin remodeling enzymes (5), and also negatively regulates the activity of the tumor suppressor p53 (6). In response to genotoxic stress, CABIN1 is degraded and releases its inhibition of p53, allowing p53 to elicit cellular stress responses (7). CABIN1 is also involved in regulation of chromatin structure as part of the highly conserved HIRA/UBN1/CABIN1/ASF1A (HUCA) histone chaperone complex (8,9).\n\nApplications: \nSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1:1000. Incubate membrane with diluted antibody in 5% w/v nonfat dry milk, 1X TBS, 0.1% Tween-20 at 4 degrees C with gentle shaking, overnight.\nImmunoprecipitation: 1:100\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

137418

Size

100ul

Applications

IP, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied in 10mM sodium HEPES, pH 7.5, 150mM NaCl, 100ug/ml BSA, 50% glycerol and <0.02% sodium azide.

P Type

Mab

Purity

Purified.

Isotype

IgG

References

1. Sun, L. et al. (1998) Immunity 8, 703-11. 2. Youn, H.D. and Liu, J.O. (2000) Immunity 13, 85-94. 3. Liu, W. et al. (2001) Eur J Immunol 31, 1757-64. 4. Kim, M.J. et al. (2002) Proc Natl Acad Sci U S A 99, 9870-5. 5. Jang, H. et al. (2007) J Biol Chem 282, 11172-9. 6. Jang, H. et al. (2009) Nat Struct Mol Biol 16, 910-5. 7. Choi, S.Y. et al. (2013) Nucleic Acids Res 41, 2180-2190. 8. Rai, T.S. et al. (2011) Mol Cell Biol 31, 4107-18. 9. Tang, Y. et al. (2012) Biochemistry 51, 2366-77.

Additional Info

Recognizes endogenous levels of total human CABIN1.

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