Home  >  Products  >  Calreticulin, Recombinant, aa18-417, His-tag (CRP55, Calregulin, Endoplasmic Reticulum Resident Protein 60, ERp60, HACBP, grp60, CRTC, CALR)

Calreticulin, Recombinant, aa18-417, His-tag (CRP55, Calregulin, Endoplasmic Reticulum Resident Protein 60, ERp60, HACBP, grp60, CRTC, CALR)

Cat no: 149797


Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an aa sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. Source: Recombinant protein corresponding to CALR, fused to His-tag at N-terminal expressed in E.coli. Molecular Weight: ~46kD Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: 149797
Size: 50ug
Form: Supplied as a liquid in 10mM Tris, pH 8.0, 0.002% sodium azide, 3mM sodium chloride.
Purity: ~90%
References: 1. Horibe,T., Matsui,H., Tanaka,M., Nagai,H., Yamaguchi,Y., Kato,K. and Kikuchi,M. Gentamicin binds to the lectin site of calreticulin and inhibits its chaperone activity Biochem. Biophys. Res. Commun. 323(1):281-287(2004).

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*

Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave