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Carbonyl Reductase 1 (CBR 1, CRN, CBR, hCBR1)

Carbonyl Reductase 1 (CBR 1, CRN, CBR, hCBR1)

Cat no: C1146-04

Supplier: United States Biological
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Carbonyl reductase is one of several monomeric, NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds. This enzyme is widely distributed in human tissues. Another carbonyl reductase gene, CRB3, lies close to this gene on chromosome 21q. Applications: Suitable for use in ELISA, Immunohistochemistry and Western Blot. Other applications have not been tested. Recommended Dilutions: Peptide ELISA Titer: 1:16,000 Western Blot: 0.2-0.5ug/ml; ~30-35kD band seen in Human Liver and Kidney lysates [Calculated MW of 30.4kD according to NP_001748.1. Immunohistochemistry: 1-2ug/ml; In paraffin embedded Human Kidney shows cytoplasmic staining of epithelial cells of renal tubules. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C1146-04
Reactivities: Human
Hosts: Goat
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by peptide affinity chromatography.
Alternative names: short chain dehydrogenase/reductase family 21C, member 1, SDR21C1, prostaglandin-E(2) 9-reductase, prostaglandin 9-ketoreductase, hCBR1, carbonyl reductase (NADPH) 1, carbonyl reductase (NADPH), CBR, carbonyl reductase 1, CBR1
References: 1. Gonzalez-Covarrubias V, Zhang J, Kalabus JL, Relling MV, Blanco JG. Pharmacogenetics of human carbonyl reductase 1 (CBR1) in livers from black and white donors. Drug Metab Dispos. 2009 Feb;37(2):400-7. PMID: 19022938 The goat polyclonal antibody used in this paper was manufactured by us: Choi I, Kim JY, Lee EJ, Kim YY, Chung CS, Chang J, Choi NJ, Chung HJ, Lee KH. Ontogeny of expression and localization of steroidogenic enzymes in the neonatal and prepubertal pig testes. J Androl. 2009 Jan-Feb;30(1):57-74. PMID: 18772489 The goat polyclonal antibody used in this paper was manufactured by us: Gavelov
Additional info: Recognizes human Carbonyl Reductase 1.

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