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Caspase-1 (CASP-1, Interleukin-1 beta Convertase, IL-1BC, Interleukin-1 beta-converting Enzyme, ICE, IL-1 beta-converting Enzyme, p45, CASP1, IL1BC, IL1BCE)

Caspase-1 (CASP-1, Interleukin-1 beta Convertase, IL-1BC, Interleukin-1 beta-converting Enzyme, ICE, IL-1 beta-converting Enzyme, p45, CASP1, IL1BC, IL1BCE)

Cat no: C2086-66W1

Supplier: United States Biological
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Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-1 (ICE, interleukin-1b-converting enzyme) is the mammalian caspase responsible for the proteolytic conversion of the proforms of interleukin-1b and IL-18 into active cytokines. Like other caspases, Caspase-1 itself is synthesized as a pro-enzyme that is cleaved during activation into a large (20kD) and small (10kD) subunits. The cellular role of caspase-1 appears limited to cytokine activation as they do not have obvious roles in apoptosis. Applications: Suitable for use in Immunofluorescence, Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Immunofluorescence: 10-20ug/ml Western Blot: 0.5-4ug/ml Immunoprecipitation: 4-8ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2086-66W1
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunofluorescence, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.5% BSA, 0.01% thimerosal, 30% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by affinity chromatography.
Additional info: Recognizes human Caspase-1. Species Crossreactivity: mouse and rat.

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