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Products Caspase-1 Monoclonal Antibody (Clone 14F468)
| Catalogue number: | 13907 |
| Hosts: | Mouse |
| Applications: | Immunohistochemistry, Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | synthetic peptide corresponding to human Caspase-1 within the region of amino acids 371-390 |
| P type: | Antibodies|Intracellular Signaling |
| Isotype: | IgG1k |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. The precursor form of all caspases is composed of a prodomain and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a tetramer to form the active enzyme. Caspase-1 is similar to the cell death gene CED-3 of C. elegans and regulates multiple proinflammatory cytokines, including interleukin-1(beta) and interferon-(gamma)-inducing factor. |
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