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Products Caspase-8 Monoclonal Antibody - biotin (Clone 90A992)
| Catalogue number: | 13914 |
| Hosts: | Mouse |
| Applications: | ELISA |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | synthetic peptide corresponding to human caspase-8 amino acids 217-222 |
| P type: | Antibodies|Intracellular Signaling |
| Isotype: | IgG1k |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. The precursor form of all caspases is composed of a prodomain and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation, and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a a2b2 tetramer to form the active enzyme. Caspase-8 (FLICE) forms a direct link between the activation of CD95 and the caspase pathway. Overexpression of caspase-8 induces apoptosis, which can be blocked by inhibitors specific for the ICE family. |
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