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Products Caspase-9 Polyclonal Antibody
| Catalogue number: | 160790 |
| Hosts: | Rabbit |
| Applications: | Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | human caspase-9 amino acids 299-318 (ASTSPEDESPGSNPEPDATP){6864,6865,6874} |
| P type: | Antibodies|Intracellular Signaling |
| Shipping temp: | 4 |
| Storage temp: | 4 |
| Additional info: | Apoptosis is related to many diseases and is induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf3. Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation. Caspase-9 is also activated by granzyme B and CPP32. Activated caspase-9 cleaves and activates caspase-3, one of the key proteases responsible for the proteolytic cleavage of many key proteins in apoptosis. Caspase-9 plays a central role in cell death induced by a wide variety of apoptosis inducers including TNF-(alpha), TRAIL, anti-CD-95, FADD, and TRADD. Caspase-9 is expressed in a variety of human tissues. |
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