CASR, ID (CASR, GPRC2A, PCAR1, Extracellular calcium-sensing receptor, Parathyroid cell calcium-sensing receptor)

The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq].\n\nApplications:\nSuitable for use in Western Blot, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

033221

Size

200ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Mouse

Form

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

O'Seaghdha, C.M., et al. Hum. Mol. Genet. 19(21):4296-4303(2010)\nGiroux, S., et al. Bone 47(5):975-981(2010)\nLetz, S., et al. J. Clin. Endocrinol. Metab. 95 (10), E229-E233 (2010) :\nRey, O., et al. J. Cell. Physiol. 225(1):73-83(2010)\nKapur, K., et al. PLoS Genet. 6 (7), E1001035 (2010) :

Additional Info

Mouse

Alternative Names

CASR, GPRC2A, PCAR1, Extracellular calcium-sensing receptor, Parathyroid cell calcium-sensing receptor