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Products CBP bromodomain TR-FRET Assay Kit
| Catalogue number: | 600850 |
| Weight: | 0 |
| Form: | 384 Well |
| P type: | Assay Kits |
| Shipping temp: | -80 |
| Storage temp: | -80 |
| Additional info: | CBP (CREB-binding protein or CREBBP) functions as a histone acetyltransferase, catalyzing the transfer of an acetyl group from the cofactor acetylCoA to the E-amine of a substrate lysine side chain. These acetylated lysine residues are recognized by bromodomains and play a critical role in the epigenetic regulation of gene transcription. CBP has also been shown to acetylate numerous non-histone proteins including various transcription factors and coactivators, some of which are related to several oncogenes and tumor suppressors. Cayman's CBP bromodomain TR-FRET Assay Kit is a homogeneous, TR-FRET assay method amenable to rapid characterization of inhibitors of bromodomain/acetylated peptide interaction in a high throughput format. This screening assay is robust, displaying a Z' >0.6. |
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