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CBP bromodomain TR-FRET Assay Kit

Cat no: 600850

CBP bromodomain TR-FRET Assay Kit

CBP (CREB-binding protein or CREBBP) functions as a histone acetyltransferase, catalyzing the transfer of an acetyl group from the cofactor acetylCoA to the E-amine of a substrate lysine side chain. These acetylated lysine residues are recognized by bromodomains and play a critical role in the epigenetic regulation of gene transcription. CBP has also been shown to acetylate numerous non-histone proteins including various transcription factors and coactivators, some of which are related to several oncogenes and tumor suppressors. Cayman's CBP bromodomain TR-FRET Assay Kit is a homogeneous, TR-FRET assay method amenable to rapid characterization of inhibitors of bromodomain/acetylated peptide interaction in a high throughput format. This screening assay is robust, displaying a Z' >0.6.

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SPECIFICATIONS

Catalog Number

600850

Form

384 Well

P Type

Assay Kits

Weight

0

Storage Temp

-80

Shipping Temp

-80

Additional Info

CBP (CREB-binding protein or CREBBP) functions as a histone acetyltransferase, catalyzing the transfer of an acetyl group from the cofactor acetylCoA to the E-amine of a substrate lysine side chain. These acetylated lysine residues are recognized by bromodomains and play a critical role in the epigenetic regulation of gene transcription. CBP has also been shown to acetylate numerous non-histone proteins including various transcription factors and coactivators, some of which are related to several oncogenes and tumor suppressors. Cayman's CBP bromodomain TR-FRET Assay Kit is a homogeneous, TR-FRET assay method amenable to rapid characterization of inhibitors of bromodomain/acetylated peptide interaction in a high throughput format. This screening assay is robust, displaying a Z' >0.6.

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