MIP-3 beta is a CC chemokine that is expressed in the thymus, lymph nodes and in activated bone marrow stromal cells and signals through the CCR7 receptor. MIP-3 beta is a chemoattractant for T and B lymphocytes and myeloid progenitor cells. Human MIP-3 beta is active on murine cells. Recombinant murine MIP-3 beta is a 9.2kD protein containing 83aa, including the four highly conserved cysteine residues present in CC chemokines.
Source:
Recombinant protein corresponding to mouse MIP-3 beta, expressed in E.coli.
Biological Activity:
Determined by its ability to chemoattract human mature dendritic cells using a concentration range of 10-100ng/ml.
Endotoxin:
<0.1ng/ug (1EU/ug)
AA Sequence:
GANDAEDCCL SVTQRPIPGN IVKAFRYLLN EDGCRVPAVV FTTLRGYQLC APPDQPWVDR IIRRLKKSSA KNKGNSTRRS PVS
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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